Gastroenterol Res

Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access

Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc

Journal website https://gr.elmerpub.com

Original Article

Volume 18, Number 3, June 2025, pages 101-107

Evaluating the Impact of Co-Existent Inflammatory Bowel Disease on Hospital-Based Outcomes Among Patients With Acute Pancreatitis: An Analysis of the 2020 National Inpatient Sample Database

**Table 1.** ICD-10-CM Diagnostic Codes to Identify Primary Diagnosis and Co-Diagnosis
Diagnosis	Code
CD and UC groups are mutually exclusive. AP: acute pancreatitis; CD: Crohn’s disease; UC: ulcerative colitis.
AP	K85.00, K85.01, K85.02, K85.80, K85.81, K85.82, K85.90, K85.91, K85.92, K85.10, K85.11, K85.12, K85.20, K85.21, K85.22, K85.30, K85.31, K85.32
UC	K51.00, K51.011, K51.20, K51.30, K51.013, K51.014, K51.018, K51.019, K51.211, K51.212, K51.213, K51.214, K51.218, K51.219, K51.311, K51.312, K51.313, K51.314, K51.318, K51.319, K51.811, K51.812, K51.813, K51.814, K51.818, K51.819, K51.911, K51.912, K51.913, K51.914, K51.918, K51.919
CD	K50.00, K50.011, K50.012, K50.013, K50.014, K50.018, K50.019, K50.10, K50.111, K50.112, K50.113, K50.114, K50.118, K50.118, K50.119, K50.80, K50.811, K50.812, K50.813, K50.814, K50.818, K50.819, K50.90, K50.911, K50.912, K50.913, K50.914, K50.918, K50.919

Table 1. ICD-10-CM Diagnostic Codes to Identify Primary Diagnosis and Co-Diagnosis

Diagnosis

Code

CD and UC groups are mutually exclusive. AP: acute pancreatitis; CD: Crohn’s disease; UC: ulcerative colitis.

K85.00, K85.01, K85.02, K85.80, K85.81, K85.82, K85.90, K85.91, K85.92, K85.10, K85.11, K85.12, K85.20, K85.21, K85.22, K85.30, K85.31, K85.32

K51.00, K51.011, K51.20, K51.30, K51.013, K51.014, K51.018, K51.019, K51.211, K51.212, K51.213, K51.214, K51.218, K51.219, K51.311, K51.312, K51.313, K51.314, K51.318, K51.319, K51.811, K51.812, K51.813, K51.814, K51.818, K51.819, K51.911, K51.912, K51.913, K51.914, K51.918, K51.919

K50.00, K50.011, K50.012, K50.013, K50.014, K50.018, K50.019, K50.10, K50.111, K50.112, K50.113, K50.114, K50.118, K50.118, K50.119, K50.80, K50.811, K50.812, K50.813, K50.814, K50.818, K50.819, K50.90, K50.911, K50.912, K50.913, K50.914, K50.918, K50.919

**Table 2.** Characteristics of Hospitalizations for AP by CD Status
Patient characteristics	CD group
AP: acute pancreatitis; CD: Crohn’s disease.
Patients, n (%)	1,930 (0.75)	257,035 (99.3)
Gender			0.015
Male	940 (48.7)	141,626 (55.1)
Female	990 (51.3)	115,409 (44.9)
Race			< 0.001
White	1,573 (81.5)	163,731 (63.7)
Black	214 (11.1)	44,724 (17.4)
Hispanic	102 (5.2)	33,672 (13.1)
Charlson Comorbidity Index score, n (%)			0.024
0	840 (43.5)	94,846 (36.9)
1	606 (31.4)	81,737 (31.8)
2	249 (12.9)	38,041 (14.8)
≥ 3	235 (12.2)	42,668 (16.6)
Insured type, n (%)			0.001
Medicaid	666 (34.5)	73,255 (28.5)
Medicare	407 (21.1)	69,656 (27.1)
Private	730 (37.8)	86,364 (33.6)
Location/teaching status of hospital			0.934
Rural	214 (11.1)	29,816 (11.6)
Urban non-teaching	396 (20.5)	53,977 (21.0)
Urban teaching	1,320 (68.4)	173,499 (67.5)
Relative bed size category of hospital			0.355
Small	481 (24.9)	70,428 (27.4)
Medium	531 (27.5)	74,283 (28.9)
Large	921 (47.7)	112,581 (43.8)
Etiologies of AP
Alcoholic AP	347 (18.0)	79,166 (30.8)	< 0.01
Biliary AP	214 (11.1)	41,897 (16.3)	< 0.01
Drug-induced AP	85 (4.4)	3,598 (1.4)	< 0.01

Table 2. Characteristics of Hospitalizations for AP by CD Status

Patient characteristics

CD group

With CD

Without CD

P-value

AP: acute pancreatitis; CD: Crohn’s disease.

Patients, n (%)

1,930 (0.75)

257,035 (99.3)

Gender

0.015

Male

940 (48.7)

141,626 (55.1)

Female

990 (51.3)

115,409 (44.9)

Race

< 0.001

White

1,573 (81.5)

163,731 (63.7)

Black

214 (11.1)

44,724 (17.4)

Hispanic

102 (5.2)

33,672 (13.1)

Charlson Comorbidity Index score, n (%)

0.024

840 (43.5)

94,846 (36.9)

606 (31.4)

81,737 (31.8)

249 (12.9)

38,041 (14.8)

≥ 3

235 (12.2)

42,668 (16.6)

Insured type, n (%)

0.001

Medicaid

666 (34.5)

73,255 (28.5)

Medicare

407 (21.1)

69,656 (27.1)

Private

730 (37.8)

86,364 (33.6)

Location/teaching status of hospital

0.934

Rural

214 (11.1)

29,816 (11.6)

Urban non-teaching

396 (20.5)

53,977 (21.0)

Urban teaching

1,320 (68.4)

173,499 (67.5)

Relative bed size category of hospital

0.355

Small

481 (24.9)

70,428 (27.4)

Medium

531 (27.5)

74,283 (28.9)

Large

921 (47.7)

112,581 (43.8)

Etiologies of AP

Alcoholic AP

347 (18.0)

79,166 (30.8)

< 0.01

Biliary AP

214 (11.1)

41,897 (16.3)

< 0.01

Drug-induced AP

85 (4.4)

3,598 (1.4)

< 0.01

**Table 3.** Characteristics of Hospitalizations for AP by UC Status
Patient characteristics	UC group
AP: acute pancreatitis; UC: ulcerative colitis.
Patients, n (%)	1,170 (0.45)	257,795 (99.5)
Gender			0.723
Male	631 (53.9)	141,787 (55.0)
Female	541 (46.2)	116,008 (45.0)
Race			0.004
White	899 (76.8)	164,473 (63.8)
Black	149 (12.7)	44,856 (17.4)
Hispanic	82 (7.0)	33,513 (13.0)
Charlson Comorbidity Index score, n (%)			0.027
0	535 (45.7)	95,126 (36.9)
1	305 (26.0)	81,979 (31.8)
2	180 (15.4)	38,154 (14.8)
≥ 3	150 (12.8)	42,536 (16.5)
Insured type, n (%)			0.021
Medicaid	293 (25.0)	73,472 (28.5)
Medicare	366 (31.3)	69,862 (27.1)
Private	449 (38.4)	86,619 (33.6)
Location/teaching status of hospital			0.028
Rural	95 (8.1)	29,904 (11.6)
Urban non-teaching	190 (16.2)	54,137 (21.0)
Urban teaching	885 (75.6)	174,012 (67.5)
Relative bed size category of hospital			0.057
Small	285 (24.4)	70,636 (27.4)
Medium	280 (23.9)	74,503 (28.9)
Large	605 (51.7)	112,914 (43.8)
Etiologies of AP
Alcoholic AP	205 (17.5)	79,401 (30.8)	< 0.01
Biliary AP	110 (9.4)	42,020 (16.3)	< 0.01
Drug-induced AP	101 (8.6)	3,609 (1.4)	< 0.01

Table 3. Characteristics of Hospitalizations for AP by UC Status

Patient characteristics

UC group

With UC

Without UC

P-value

AP: acute pancreatitis; UC: ulcerative colitis.

Patients, n (%)

1,170 (0.45)

257,795 (99.5)

Gender

0.723

Male

631 (53.9)

141,787 (55.0)

Female

541 (46.2)

116,008 (45.0)

Race

0.004

White

899 (76.8)

164,473 (63.8)

Black

149 (12.7)

44,856 (17.4)

Hispanic

82 (7.0)

33,513 (13.0)

Charlson Comorbidity Index score, n (%)

0.027

535 (45.7)

95,126 (36.9)

305 (26.0)

81,979 (31.8)

180 (15.4)

38,154 (14.8)

≥ 3

150 (12.8)

42,536 (16.5)

Insured type, n (%)

0.021

Medicaid

293 (25.0)

73,472 (28.5)

Medicare

366 (31.3)

69,862 (27.1)

Private

449 (38.4)

86,619 (33.6)

Location/teaching status of hospital

0.028

Rural

95 (8.1)

29,904 (11.6)

Urban non-teaching

190 (16.2)

54,137 (21.0)

Urban teaching

885 (75.6)

174,012 (67.5)

Relative bed size category of hospital

0.057

Small

285 (24.4)

70,636 (27.4)

Medium

280 (23.9)

74,503 (28.9)

Large

605 (51.7)

112,914 (43.8)

Etiologies of AP

Alcoholic AP

205 (17.5)

79,401 (30.8)

< 0.01

Biliary AP

110 (9.4)

42,020 (16.3)

< 0.01

Drug-induced AP

101 (8.6)

3,609 (1.4)

< 0.01

**Table 4.** Results of Multivariate Regression Analysis With UC as a Main Determinant Factor of Patient’s Outcomes
Outcomes	UC group
Each row represents the results of an independent multivariate regression after controlling for age, gender, race, Charlson comorbidity index, median annual income, insurance type, region of hospital, hospital bed size, and hospital teaching status. aOR: adjusted odds ratio; LL: lower limit; UC: ulcerative colitis; UL: upper limit.
In-hospital mortality	3.616		1.872	1.310, 9.978	0.013
Length of stay (days)		0.080	0.243	-0.396, 0.557	0.741
Hypovolemic shock	3.924		2.859	0.941, 16.370	0.061
Sepsis with or without shock	2.661		1.368	0.971, 7.291	0.057
Acute kidney injury	1.187		0.245	0.792, 1.778	0.407

Table 4. Results of Multivariate Regression Analysis With UC as a Main Determinant Factor of Patient’s Outcomes

Outcomes

UC group

aOR

Linearized coefficient

Standard error

95% confidence interval (LL, UL)

P- value

Each row represents the results of an independent multivariate regression after controlling for age, gender, race, Charlson comorbidity index, median annual income, insurance type, region of hospital, hospital bed size, and hospital teaching status. aOR: adjusted odds ratio; LL: lower limit; UC: ulcerative colitis; UL: upper limit.

In-hospital mortality

3.616

1.872

1.310, 9.978

0.013

Length of stay (days)

0.080

0.243

-0.396, 0.557

0.741

Hypovolemic shock

3.924

2.859

0.941, 16.370

0.061

Sepsis with or without shock

2.661

1.368

0.971, 7.291

0.057

Acute kidney injury

1.187

0.245

0.792, 1.778

0.407

**Table 5.** Results of Multivariate Regression Analysis With CD as a Main Determinant Factor of Patient’s Outcomes
Outcomes	CD group
Each row represents the results of an independent multivariate regression after controlling for age, gender, race, Charlson comorbidity index, median annual income, insurance type, region of hospital, hospital bed size, and hospital teaching status. In-hospital mortality or hypovolemic shoch were not included as outcomes, there were no cases in this study sample. aOR: adjusted odds ratio; LL: lower limit; CD: Crohn’s disease; UL: upper limit.
Length of stay		0.006	0.241	-0.468, 0.479	0.982
Sepsis with or without shock	1.741			0.642, 4.720	0.276
Acute kidney injury	1.375			1.004, 1.880	0.047

Table 5. Results of Multivariate Regression Analysis With CD as a Main Determinant Factor of Patient’s Outcomes

Outcomes

CD group

aOR

Linearized coefficient

Standard error

95% confidence interval (LL, UL)

P- value

Each row represents the results of an independent multivariate regression after controlling for age, gender, race, Charlson comorbidity index, median annual income, insurance type, region of hospital, hospital bed size, and hospital teaching status. In-hospital mortality or hypovolemic shoch were not included as outcomes, there were no cases in this study sample. aOR: adjusted odds ratio; LL: lower limit; CD: Crohn’s disease; UL: upper limit.

Length of stay

0.006

0.241

-0.468, 0.479

0.982

Sepsis with or without shock

1.741

0.642, 4.720

0.276

Acute kidney injury

1.375

1.004, 1.880

0.047