Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
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Original Article

Volume 18, Number 3, June 2025, pages 129-138


Impact of Hospital Teaching Status on Outcomes of Acute Cholangitis: A Propensity-Matched Analysis of Hospitalizations in the United States

Figures

Figure 1.
Figure 1. Comparison of inpatient mortality in acute cholangitis in teaching vs. non-teaching hospitals. National Inpatient Sample database (2016 - 2020).
Figure 2.
Figure 2. Primary and secondary outcomes of acute cholangitis: comparative analysis between teaching and non-teaching hospitals. National Inpatient Sample database (2016 - 2020). CVC: central venous catheter; ERCP: endoscopic retrograde cholangiopancreatography; Gall Pan: gallstone pancreatitis; ICU: intensive care unit; PSC: primary sclerosing cholangitis.

Tables

Table 1. Baseline Patient Characteristics of Acute Cholangitis in Non-Teaching Hospitals
 
20162017201820192020
National Inpatient Sample database (2016 - 2020). CHF: congestive heart failure.
Total, 6,7651,5751,4101,4351,2301,110
  Female895 (56.83%)790 (56.03%)630 (43.75%)620 (50.41%)530 (47.75%)
Comorbidities
  Alcohol50 (3.17%)35 (2.48%)40 (2.78%)30 (2.44%)25 (2.25%)
  CHF205 (13.02%)245 (17.38%)235 (16.32%)210 (17.07%)135 (12.16%)
  Hypertension1,030 (65.40%)980 (69.50%)1,065 (73.96%)885 (71.95%)785 (70.72%)
  Diabetes mellitus475 (30.16%)460 (32.62%)465 (32.29%)370 (30.08%)280 (25.23%)
  Cirrhosis45 (2.86%)45 (3.19%)35 (2.43%)55 (4.47%)20 (1.80%)
Race
  White1160 (76.32%)1025 (75.65%)1100 (78.01%)920 (79.31%)860 (80.75%)
  Black85 (5.59%)65 (4.80%)45 (3.19%)20 (1.72%)20 (1.88%)
  Hispanic135 (8.88%)160 (11.81%)140 (9.93%)110 (9.48%)85 (7.98%)
  Asian or Pacific Islander120 (7.89%)75 (5.54%)70 (4.96%)70 (6.03%)70 (6.57%)
  Native American10 (0.66%)10 (0.74%)5 (0.35%)0 (0.0%)0 (0.0%)
  Other10 (0.66%)20 (1.48%)50 (3.55%)40 (3.45%)30 (2.82%)
Age group
  18 - 3045 (2.86%)60 (4.26%)25 (1.74%)30 (2.44%)15 (1.40%)
  31 - 4055 (3.49%)35 (2.48%)20 (1.39%)35 (2.85%)20 (1.86%)
  41 - 5080 (5.08%)80 (5.67%)70 (4.86%)65 (5.28%)64 (6.05%)
  51 - 60195 (12.38%)145 (10.28%)155 (10.76%)130 (10.57%)110 (10.23%)
  61 - 70290 (18.41%)265 (18.79%)360 (25.00%)270 (21.96%)170 (15.81%)
  71 - 80390 (24.76%)340 (24.11%)350 (24.31%)310 (25.20%)295 (27.44%)
  > 80520 (33.02%)485 (34.40%)460 (31.94%)390 (31.71%)400 (37.21%)

 

Table 2. Baseline Patient Characteristics of Acute Cholangitis in Teaching Hospitals
 
20162017201820192020
National Inpatient Sample database (2016 - 2020). CHF: congestive heart failure.
Total, 23,5353,8954,5154,9455,2204,960
  Female2,000 (51.35%)2,415 (53.49%)2,595 (52.48%)2,650 (50.77%)2,440 (49.19%)
Comorbidities
  Alcohol155 (3.98%)130 (2.88%)160 (3.24%)160 (3.07%)195 (3.93%)
  CHF540 (13.86%)685 (15.17%)890 (18.0%)890 (17.05%)940 (18.95%)
  Hypertension2,705 (69.45%)2,965 (65.67%)3,315 (67.04%)3,680 (70.50%)3,385 (68.25%)
  Diabetes mellitus1,160 (29.78%)1,245 (27.57%)1,525 (30.84%)1,670 (31.99%)1,620 (32.66%)
  Cirrhosis140 (3.59%)125 (2.77%)210 (4.25%)245 (4.69%)210 (4.23%)
Race
  White2,515 (68.90%)2,990 (69.05%)3,245 (67.46%)3,555 (69.84%)3,370 (69.92%)
  Black240 (6.58%)245 (5.66%)310 (6.44%)325 (6.39%)280 (5.81%)
  Hispanic500 (13.70%)580 (13.39%)715 (14.86%)600 (11.79%)690 (14.32%)
  Asian or Pacific Islander225 (6.16%)300 (6.93%)344 (7.17%)355 (6.97%)325 (6.74%)
  Native American30 (0.82%)25 (0.58%)45 (0.94%)45 (0.88%)50 (1.04%)
  Other140 (3.84%)190 (4.39%)150 (3.12%)210 (4.13%)105 (2.18%)
Age group
  18 - 30130 (3.34%)165 (3.65%)135 (2.73%)115 (2.20%)135 (2.86%)
  31 - 40135 (3.47%)195 (4.32%)230 (4.65%)180 (3.45%)160 (3.39%)
  41 - 50210 (5.39%)245 (5.43%)315 (6.37%)265 (5.08%)265 (5.61%)
  51 - 60550 (14.12%)560 (12.40%)520 (10.52%)700 (13.41%)510 (10.81%)
  61 - 70785 (20.15%)925 (20.49%)1,085 (21.94%)1,080 (20.69%)985 (20.87%)
  71 - 80925 (23.75%)910 (20.16%)1,070 (21.64%)1,190 (22.80%)1,065 (22.56%)
  > 801,160 (29.78%)1,515 (33.55%)1,590 (32.15%)1,690 (32.38%)1,600 (33.90%)

 

Table 3. Baseline Patients Characteristics Comparisona for Non-Teaching vs. Teaching Hospitals in Patients With Acute Cholangitis
 
Non-teaching hospitalsTeaching hospitalsP-value
aAfter matching propensity score 1:1 to adjust baseline differences. National Inpatient Sample database (2016 - 2020). CHF: congestive heart failure.
Total6,7656,505
  Female3,330 (51.19%)3,180.0 (48.89%)0.0085
Race< 0.001
  White5,065.0 (77.86%)4,730.0 (72.71%)
  Black235.0 (3.61%)300.0 (4.61%)
  Other1,205.0 (18.52%)1,475.0 (22.67%)
Comorbidities
  CHF970.0 (14.91%)875.0 (13.45%)0.017
  Hypertension4,595.0 (70.64%)3,860.0 (59.34%)< 0.0001
  Diabetes mellitus1,970.0 (30.28%)1,880.0 (28.90%)0.0839
  Alcohol abuse170.0 (2.61%)250.0 (3.84%)< 0.0001
  Cirrhosis195.0 (3.00%)330.0 (5.07%)< 0.0001

 

Table 4. Primary and Secondary Outcomes Variables for Patients With Acute Cholangitis in Non-Teaching vs. Teaching Hospitalsa
 
Non-teaching hospitalsTeaching hospitalsP-value
aAfter matching propensity score 1:1 to adjust baseline differences; National Inpatient Sample database (2016 - 2020). CVC: central venous catheter; ERCP: endoscopic retrograde cholangiopancreatography; ICU: intensive care unit; PSC: primary sclerosing cholangitis.
Total6,5056,505
Primary outcomes
  Inpatient mortality135.0 (2.08%)180.0 (2.77%)0.0103
  Length of hospital stay (days)5.54 (± 10.87)6.38 (± 16.12)
  Total hospitalization costs (USD)18,547 (± 40,714)21,251 (± 52,898)
Secondary outcomes
  Septic shock815.0 (12.53%)1,045 (16.06%)< 0.0001
  Intubation225.0 (3.46%)345.0 (5.30%)< 0.0001
  ICU330.0 (5.07%)430.0 (6.61%)0.0002
  CVC150.0 (2.31%)145.0 (2.23%)0.7684
  ERCP160.0 (2.46%)170 (2.61%)0.5771
Etiology
  Gallstone1,105.0 (16.22%)940.0 (14.45%)0.0051
  Biliary stricture110.0 (1.69%)125.0 (1.92%)0.3234
  PSC0.0 (0.0%)5.0 (0.08%)0.0253

 

Table 5. Primary and Secondary Outcome Trends in Acute Cholangitis in Non-Teaching Hospitals
 
20162017201820192020P-value
National Inpatient Sample database (2016 - 2020). CVC: central venous catheter; ICU: intensive care unit; PSC: primary sclerosing cholangitis.
Total, 6,7601,5751,4101,4351,2301,110
Primary outcomes
  Inpatient mortality40 (2.54%)30 (2.13%)45 (3.14%)10 (0.81%)20 (1.80%)0.0008
  Length of stay (days)6.295.725.674.804.93
  Total hospitalization costs (USD)19,99318,89519,30817,78118,763
Secondary outcomes
  Septic shock195 (12.38%)155 (10.99%)170 (11.81%)190 (15.45%)120 (10.81%)0.0028
  Intubation80 (5.08%)45 (3.19%)60 (4.17%)20 (1.63%)30 (2.70%)< 0.0001
  ICU110 (6.98%)70 (4.96%)100 (6.94%)25 (2.03%)35 (3.15%)< 0.0001
  Pressors15 (0.95%)20 (1.42%)35 (2.43%)35 (2.85%)20 (1.80%)0.0013
  CVC50 (3.17%)25 (1.77%)60 (4.17%)5 (0.41%)10 (0.90%)< 0.0001
Etiology
  Biliary stricture25 (1.59%)5 (0.35%)35 (2.43%)35 (2.85%)10 (0.90%)< 0.0001
  Gallstone275 (17.46%)230 (16.31%)210 (14.58%)240 (19.51%)150 (13.51%)0.0004
  Choledocholithiasis0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)
  PSC0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)

 

Table 6. Primary and Secondary Outcome Trends in Acute Cholangitis in Teaching Hospitals
 
20162017201820192020P-value
National Inpatient Sample database (2016 - 2020). CVC: central venous catheter; ICU: intensive care unit; PSC: primary sclerosing cholangitis.
Total, 23,5353,8954,5154,9455,2204,960
Primary outcomes
  Inpatient mortality135 (3.48%)135 (2.99%)115 (2.33%)175 (3.35%)150 (3.02%)0.0117
  Length of stay (days)6.346.416.686.086.42
  Total hospitalization costs (USD)20,28720,85821,70321,25523,902
Secondary outcomes
  Septic shock600 (15.40%)670 (14.84%)845 (17.09%)760 (14.56%)805 (16.23%)0.0028
  Intubation195 (5.01%)210 (4.65%)245 (4.95%)170 (3.26%)205 (4.13%)< 0.0001
  ICU250 (6.42%)290 (6.42%)345 (6.98%)210 (4.02%)255 (5.14%)< 0.0001
  Pressors75 (1.93%)115 (2.55%)180 (3.64%)195 (3.74%)185 (3.73%)< 0.0001
  CVC110 (2.82%)100 (2.21%)145 (2.93%)50 (0.96%)75 (1.51%)< 0.0001
Etiology
  Biliary stricture90 (2.31%)90 (1.99%)110 (2.22%)90 (1.72%)165 (3.33%)< 0.0001
  Gallstone530 (13.61%)675 (14.95%)780 (15.77%)770 (14.75%)640 (12.90%)0.0005
  Choledocholithiasis0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)
  PSC0 (0.0%)0 (0.0%)5 (0.10%)20 (0.38%)0 (0.0%)< 0.0001

 

Table 7. Primary and Secondary Outcomes Variables for Patients Who Underwent ERCP in Non-Teaching vs. Teaching Hospitalsa
 
Non-teaching hospitalsTeaching hospitalsP-value
aAfter matching propensity score 1:1 to adjust baseline differences. National Inpatient Sample database (2016 - 2020). CVC: central venous catheter; ERCP: endoscopic retrograde cholangiopancreatography; ICU: intensive care unit.
Total165430
Inpatient mortality015 (3.49%)0.0260
Septic shock10 (6.06%)65 (15.12%)0.0238
Intubation010 (2.33%)0.0693
ICU010 (2.33%)0.0693
CVC00

 

Table 8. Comparison of ERCP Complicationsa for Non-Teaching vs. Teaching Hospitals in Patients With Acute Cholangitis
 
Non-teaching hospitalsTeaching hospitalsP-value
aAfter matching propensity score 1:1 to adjust baseline differences. National Inpatient Sample database (2016 - 2020). ERCP: endoscopic retrograde cholangiopancreatography; PEP: post-ERCP pancreatitis.
Total165430
PEP020 (4.65%)0.0136
Cholecystitis30 (18.18%)105 (24.42%)0.0065
Bleeding05 (1.16%)0.1904
Perforation00