Gastroenterology Research, ISSN 1918-2805 print, 1918-2813 online, Open Access
Article copyright, the authors; Journal compilation copyright, Gastroenterol Res and Elmer Press Inc
Journal website https://gr.elmerpub.com

Original Article

Volume 19, Number 4, August 2026, pages 226-232

Comparison of Clostridioides difficile Infection Incidence in Cirrhotic Patients Receiving Secondary Spontaneous Bacterial Peritonitis Prophylaxis With Ciprofloxacin vs. Trimethoprim-Sulfamethoxazole

Tables

↓  Table 1. Baseline Characteristics of the Study Population
 
CharacteristicValue
IQR: interquartile range; CDI: Clostridioides difficile infection; TMP-SMX: trimethoprim- sulfamethoxazole.
Total encounters6,948
Age, median (IQR)54 (45, 61)
Female30.1%
White78.6%
Black or African American9.4%
American Indian/Alaska Native3.9%
Asian1.6%
Other6.1%
Multiracial14.1%
Not Hispanic or Latino80.9%
Hispanic or Latino19.1%
CDI cases32 (0.5%)
Mortality20 (0.3%)
Ciprofloxacin5,236 (75.4%)
TMP-SMX1,712 (24.6%)
Medication duration (days)77 (36, 165)

 

↓  Table 2. Group Comparison by Medication
 
CharacteristicCiprofloxacin (n = 5,236)TMP-SMX (n = 1,712)
IQR: interquartile range; CDI: Clostridioides difficile infection; TMP-SMX: trimethoprim- sulfamethoxazole.
Age, median (IQR)54 (45, 61)53 (44, 60)
Female29.7%31.3%
White79.3%76.4%
Black or African American9.2%9.7%
American Indian/Alaska Native3.3%5.8%
Asian1.5%1.7%
Other6.2%5.8%
Multiracial14.1%14.3%
Not Hispanic or Latino80.3%82.6%
Hispanic or Latino19.7%17.4%
CDI cases21 (0.4%)11 (0.6%)
Mortality17 (0.3%)< 11
Medication duration (days)77 (36, 167)73 (37, 160)

 

↓  Table 3. GEE Model: CDI Risk
 
ComparisonOR95% CIP-value
GEE: generalized estimating equation; CDI: Clostridioides difficile infection; OR: odds ratio; CI: confidence interval; TMP-SMX: trimethoprim-sulfamethoxazole.
Ciprofloxacin vs. TMP-SMX0.623(0.299, 1.296)0.206

 

↓  Table 4. GEE Model: Mortality Risk
 
ComparisonOR95% CIP-value
GEE: generalized estimating equation; OR: odds ratio; CI: confidence interval; TMP-SMX: trimethoprim-sulfamethoxazole.
Ciprofloxacin vs. TMP-SMX0.539(0.158, 1.844)0.320